Elimination Guidelines (April 3, 2023)

Warning

It is stressed that these results are presented as guidelines only and should not be construed as absolute for every horse to which this drug is administered.

The guidelines in this booklet may not apply to a compounded product and may not be consistent with foreign regulations and laboratory methods.

Elimination Guidelines Revision Date April 3, 2023 (PDF Version, 1.03 MB)

Glossary

Routes of Administration
  • Aeromask Inhaler (AER)
  • Infiltration (INFIL)
  • Intra-articular Injection (IA)
  • Intramuscular Injection (IM)
  • Intra-synovial Injection (ISY)
  • Intratracheal (IT)
  • Intravenous Injection (IV)
  • Nebulization (NEB)
  • Oral (PO)
  • Subcutaneous Injection (SC)
  • Sublingual (SL)
  • Topical (TOP)
Dosage Regimen and Elimination Guideline (EG)
Explanation about the Dosage Regimen and Elimination Guideline
Number (#) of horses Trade Name Dose e.g. 500 mg (milligrams)
Standardbred mares Of product administered 1g (1 gram = 1000 mg)
Elimination Guideline

Sample time, after final dose, after which no drug or metabolite was detected using current methodology.

Example: Elimination guideline = 120+ hours (h): At this dosage, most horses would test positive for longer than 120 hours after the last treatment.

Type of Drug Glossary

Drug administration data (alphabetical listing)

 

A

Acepromazine

Trade and Other Names:
Acetylpromazine, Acetazine, Atravet, Anatran, Aceprozine, Tranozine, Tranquavet
Type of Drug:
Tranquilizer
Route of Administration:
IM, IV, Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Acepromazine
#Horses Product Dose/Route Administration EG
4 Atravet 10 mg PO single 24 h
6 Atravet 10 mg PO once daily, 3 days 24 h
8 Atravet 50 mg PO single 36 h
6 Atravet 10 mg IM single 36 h
8 Atravet 25 mg IM single 36 h
8 Atravet 25 mg IV single 36 h

Acetaminophen

Trade and Other Names:
Paracetamol, Atasol, Tylenol, Exdol, Dolophen, Paraphen, Robigesic
Type of Drug:
Analgesic; Antipyretic
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Acetaminophen
#Horses Product Dose/Route Administration EG
4 Atasol 8 g PO single 96 h
4 Tylenol 10 g PO single 96 h

Aminocaproic Acid

Trade and Other Names:
Amicar
Type of Drug:
Antifibrinolytic
Route of Administration:
IV
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Aminocaproic Acid
#Horses Product Dose/Route Administration EG
4 Amicar 2.5 g IV single 48 h
4 Amicar 5.0 g IV single 48 h

Atropine

Trade and Other Names:
Atropine Sulfate
Type of Drug:
Anticholinergic
Route of Administration:
IV
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Atropine
#Horses Product Dose/Route Administration EG
4 Atropine sulfate 7 mg IV single 24 h

B

Beclomethasone

Trade and Other Names:
Qvar
Type of Drug:
Corticosteroid
Route of Administration:
AER
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Beclomethasone
#Horses Product Dose/Route Administration EG
4 Qvar 4 mg AER single 48 h

Betamethasone

Trade and Other Names:
Celestone Soluspan
Type of Drug:
Corticosteroid
Route of Administration:
IA
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Betamethasone
#Horses Product Dose/Route Administration EG
4 Celestone Soluspan 18 mg IA single 6 days

Bupivacaine

Trade and Other Names:
Marcaine
Type of Drug:
Local anesthetic
Route of Administration:
IM
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Bupivacaine
#Horses Product Dose/Route Administration EG
8 Marcaine 50 mg IM single 24 h

Butorphanol

Trade and Other Names:
Torbugesic
Type of Drug:
Opioid
Route of Administration:
IV
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Butorphanol
#Horses Product Dose/Route Administration EG
4 Torbugesic 5 mg IV single 48 h
4 Torbugesic 20 mg IV single 72 h

N-Butylhyoscine

Trade and Other Names:
Buscopan
Type of Drug:
Anticholinergic
Route of Administration:
IV, Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for N-Butylhyoscine
#Horses Product Dose/Route Administration EG
4 Buscopan 140 mg IV single 24 h
4 Buscopan 140 mg PO single 24 h

C

Carbazochrome

Trade and Other Names:
Kentucky Red
Type of Drug:
Hemostatic
Route of Administration:
IV
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Carbazochrome
#Horses Product Dose/Route Administration EG
4 Kentucky Red 100 mg IV single 24 h

Carprofen

Trade and Other Names:
Rimadyl
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Carprofen
#Horses Product Dose/Route Administration EG
4 Rimadyl 1 g PO twice daily, 5 days 120+ h

Note: At this dosage, most horses would test positive for longer than 120 hours after the last treatment.

Cetirizine

Trade and Other Names:
Reactine
Type of Drug:
Antihistamine
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Cetirizine
#Horses Product Dose/Route Administration EG
4  Reactine 200 mg PO single 72 h

Chloroprocaine

Trade and Other Names:
Nesacaine
Type of Drug:
Local Anesthetic
Route of Administration:
INFIL
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Chloroprocaine
#Horses Product Dose/Route Administration EG
4 Nesacaine 80 mg INFIL single 24 h

Chlorpheniramine

Trade and Other Names:
Chlortripolon, Histalon, Novopheniram, Chlorophen, Inactihist
Type of Drug:
Antihistamine
Route of Administration:
IM
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Chlorpheniramine
#Horses Product Dose/Route Administration EG
8 Inactihist 75 mg IM single 72 h

Chlorpromazine

Trade and Other Names:
Largactil, Chlorpromanyl, Chlorprom, G Promazine, Apo Chlorpromazine, Novochlorpromazine
Type of Drug:
Tranquilizer
Route of Administration:
IM
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Chlorpromazine
#Horses Product Dose/Route Administration EG
4 Largactil 100 mg IM single 96 h

Ciclesonide

Trade and Other Names:
Aservo EquiHaler
Type of Drug:
Corticosteroid
Route of Administration:
AER
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Ciclesonide
#Horses Product Dose/Route Administration EG
4 Aservo EquiHaler[a] 2744 µg AER 
4116 µg AER		 twice daily, 5 days followed by
5 days once daily		 48 h
[a] The CPMA does not have any information about ciclesonide elimination using other formulations or drug delivery systems. Therefore, this Elimination Guideline should be applied with caution to any formulation or drug delivery system other than the Aservo EquiHaler.

Cimetidine

Trade and Other Names:
Tagamet, Peptol
Type of Drug:
Histamine H2 Receptor Antagonist
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Cimetidine
#Horses Product Dose/Route Administration EG
4 Tagamet 4 g PO twice daily, 3 days 48 h

Clenbuterol

Trade and Other Names:
Ventipulmin
Type of Drug:
Bronchodilator
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Clenbuterol
#Horses Product Dose/Route Administration EG
4 Ventipulmin 0.40 mg PO twice daily, 5 days 28 days

Clodronate – only applies to 4 year olds and older

Trade and Other Names:
Osphos
Type of Drug:
Bisphosphonate
Route of Administration:
IM, in three separate locations
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Clodronate
#Horses Product Dose/Route Administration EG
5 Osphos 720 mg IM single 30 days

Clomipramine

Trade and Other Names:
Clomicalm
Type of Drug:
Antidepressant
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Clomipramine
#Horses Product Dose/Route Administration EG
4 Clomicalm 500 mg PO twice daily, 4 days 120+ h

Note: At this dosage, most horses would test positive for longer than 120 hours after the last treatment.

Cromoglycate

Trade and Other Names:
Cromovet, Cromolyn, Intal
Type of Drug:
Mast cell stabilizer
Route of Administration:
NEB, AER
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Cromoglycate
#Horses Product Dose/Route Administration EG
4 Cromovet 80 mg NEB single 24 h
2 Cromovet 80 mg NEB once daily, 3 days 24 h
4 Intal 10 mg AER single 24 h

Cyproheptadine

Trade and Other Names:
Periactin
Type of Drug:
Antihistamine
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Cyproheptadine
#Horses Product Dose/Route Administration EG
4 Periactin 40 mg PO once daily, 5 days 48 h

D

Dantrolene

Trade and Other Names:
Dantrium, Dantrolene Oral suspension
Type of Drug:
Skeletal Muscle Relaxant
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Dantrolene
#Horses Product Dose/Route Administration EG
4 Dantrium 1.5 g PO single 48 h
4 Dantrolene Oral suspension 1 g PO once daily, 5 days 60 h

Dembrexine

Trade and Other Names:
Sputolysin
Type of Drug:
Mucolytic; Expectorant
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Dembrexine
#Horses Product Dose/Route Administration EG
4 Sputolysin 150 mg PO twice daily, 4 days 72 h

Detomidine

Trade and Other Names:
Dormosedan
Type of Drug:
Analgesic, sedative
Route of Administration:
IV, SL
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Detomidine
#Horses Product Dose/Route Administration EG
4 Dormosedan 5 mg IV single 36 h
4 Dormosedan 20 mg IV single 72 h
4 Dormosedan 22.8 mg SL single 72 h

Dexamethasone

Trade and Other Names:
Dexamethasone 5, Dexamethasone Powder
Type of Drug:
Corticosteroid
Route of Administration:
IV, Oral (PO), IM
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Dexamethasone
#Horses Product Dose/Route Administration EG
4 Dexamethasone 5 25 mg IV single 48 h
4 Dexamethasone Powder 10 mg PO once daily, 5 days 48 h
4 Dexamethasone 5 20 mg IM Single 48 h

Dextromethorphan

Trade and Other Names:
Democineol, Sedatuss, Broncho Grippol, Tussorphan, Robidex, Balminil
Type of Drug:
Antitussive
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Dextromethorphan
#Horses Product Dose/Route Administration EG
4 Dextromethorphan syrup 300 mg PO single 96 h

Diazepam

Trade and Other Names:
Valium, APO Diazepam
Type of Drug:
Tranquilizer
Route of Administration:
IM, Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Diazepam
#Horses Product Dose/Route Administration EG
4 Valium 10 mg IM single 120+ h
4 Apo Diazepam 30 mg PO once daily, 5 days 120+ h

Note: At this dosage, most horses would test positive for longer than 120 hours after the last treatment.

Diclofenac

Trade and Other Names:
Voltaren; Diclofenac Sodium Gel
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO), TOP (as leg rub)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Diclofenac
#Horses Product Dose/Route Administration EG
8 Voltaren 500 mg PO single 36 h
4 Diclofenac Sodium gel 180 mg TOP twice daily, 5 days 120 h

Diflunisal

Trade and Other Names:
Dolobid
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Diflunisal
#Horses Product Dose/Route Administration EG
8 Dolobid 5 g PO single 96 h

Dimethylsulfoxide

Trade and Other Names:
DMSO, Domoso, Rimso, Kemsol
Type of Drug:
Analgesic/Anti-inflammatory (NSAID); Penetrant Carrier
Route of Administration:
TOP (as leg rub), IV
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Dimethylsulfoxide
#Horses Product Dose/Route Administration EG
4 Domoso Gel 90% 19.8 g TOP single 36 h
2 Domoso Solution 19.8 g IV single 36 h

Diphenhydramine

Trade and Other Names:
Benadryl, Sominex, Compoz, Nytol
Type of Drug:
Antihistamine
Route of Administration:
IM, Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Diphenhydramine
#Horses Product Dose/Route Administration EG
4 Benadryl 250 mg IM single 48 h
4 Benadryl 500 mg PO single 48 h

Dipyrone

Trade and Other Names:
Methampyrone, Novolate, Diprone, Novin, Myovin, Dipyrone 50%, Metamizol
Type of Drug:
Analgesic / Anti-inflammatory (NSAID)
Route of Administration:
IM, IV
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Dipyrone
#Horses Product Dose/Route Administration EG
8 Dipyrone 50% 7.5 g IM single 36 h
4 Novolate 7.5 g IV single 36 h
4 Dipyrone 50% 10 g IM twice daily, 5 days 120 h

Dyphylline

Trade and Other Names:
Protophylline
Type of Drug:
Bronchodilator
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Dyphylline
#Horses Product Dose/Route Administration EG
4 Protophylline 5 g PO single 96 h

E

Enalapril

Trade and Other Names:
Enacard
Type of Drug:
Antihypertensive
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Enalapril
#Horses Product Dose/Route Administration EG
4 Enacard 60 mg PO once daily, 5 days 72 h

Ephedrine

Trade and Other Names:
Antiphrine, Anti-Histamine (also contains Pyrilamine)
Type of Drug:
Sympathomimetic, anti-congestive
Route of Administration:
IM, Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Ephedrine
#Horses Product Dose/Route Administration EG
4 Antiphrine 200 mg PO single 36 h
4 Anti-Histamine 200 mg IM single 36 h
4 Oral Anti-Histamine 300 mg PO twice daily, 6 days 48  h

Ergonovine

Trade and Other Names:
Ergonovine Maleate
Type of Drug:
Oxytocic
Route of Administration:
IV
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Ergonovine
#Horses Product Dose/Route Administration EG
4 Ergonovine Maleate 2 mg IV single 36 h
4 Ergonovine Maleate 4 mg IV single 60 h

Ethacrynic Acid

Trade and Other Names:
Edecrin
Type of Drug:
Diuretic
Route of Administration:
IV, Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Ethacrynic Acid
#Horses Product Dose/Route Administration EG
8 Edecrin 50 mg IV single 36 h
4 Edecrin 200 mg PO single 48 h
4 Edecrin 400 mg PO single 48 h

Etodolac

Trade and Other Names:
Ultradol
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Etodolac
#Horses Product Dose/Route Administration EG
4 Ultradol 2 g PO single 96 h

F

Famotidine

Trade and Other Names:
Pepcid, Ulcidine
Type of Drug:
Histamine H2 Receptor Antagonist
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Famotidine
#Horses Product Dose/Route Administration EG
4 Pepcid 200 mg PO single 72 h

Fenoterol

Trade and Other Names:
Berotec
Type of Drug:
Bronchodilator
Route of Administration:
AER
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Fenoterol
#Horses Product Dose/Route Administration EG
4 Berotec 1 mg AER single 24 h

Firocoxib

Trade and Other Names:
Previcox
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Firocoxib
#Horses Product Dose/Route Administration EG
4 Previcox 57 mg PO once daily, 5 days 14 days

Floctafenine

Trade and Other Names:
Idarac
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Floctafenine
#Horses Product Dose/Route Administration EG
4 Idarac 2 g PO single 96 h

Flunixin

Trade and Other Names:
Banamine
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
IV, Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Flunixin
#Horses Product Dose/Route Administration EG
4 Banamine 500 mg PO single 48 h
6 Banamine 500 mg IV single 48 h

Fluphenazine

Trade and Other Names:
Modecate
Type of Drug:
Tranquilizer/Sedative
Route of Administration:
IM
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Fluphenazine
#Horses Product Dose/Route Administration EG
4 Modecate 50 mg IM single 42 days

Flurbiprofen

Trade and Other Names:
Ansaid
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Flurbiprofen
#Horses Product Dose/Route Administration EG
4 Ansaid 2 g PO single 60 h

Fluticasone

Trade and Other Names:
Flovent
Type of Drug:
Corticosteroid
Route of Administration:
AER
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Fluticasone
#Horses Product Dose/Route Administration EG
5 Flovent 2 mg AER twice daily, 7 days 24 h

Fluticasone / Salmeterol

Trade and Other Names:
Advair 250
Type of Drug:
Corticosteroid / Bronchodilator
Route of Administration:
AER
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Fluticasone/Salmeterol
#Horses Product Dose/Route Administration EG
5 Advair 250 2.5 mg/ 250µg AER twice daily, 7 days 24 h

Furosemide

Trade and Other Names:
Lasix, Salix, Lasix Special
Type of Drug:
Diuretic
Route of Administration:
IV, IM, Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Furosemide
#Horses Product Dose/Route Administration EG
12 Lasix 150 mg IV single 24 h
2 Lasix 200 mg IV single 24 h
12 Lasix 250 mg IV single 24 h
4 Lasix 400 mg IV single 24 h
2 Lasix 200 mg IV once daily, 3 days 24 h
2 Lasix 200 mg IM single 24 h
4 Lasix 400 mg IM single 24 h
2 Lasix 200 mg IM once daily, 3 days 24 h
4 Lasix Special 2 g PO single 36 h

G

Glycopyrrolate

Trade and Other Names:
Robinul
Type of Drug:
Anticholinergic
Route of Administration:
IV, IM
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Glycopyrrolate
#Horses Product Dose/Route Administration EG
4 Robinul 2 mg IV single 36 h
4 Robinul 2 mg IM single 48 h

Guaifenesin

Trade and Other Names:
Glyceryl Guaiacolate, Guaiacol Glyceryl Ether Gecolate, Robitussin
Type of Drug:
Expectorant
Route of Administration:
IV, Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Guaifenesin
#Horses Product Dose/Route Administration EG
4 Gecolate 2 g IV single 24 h
4 Guaifenesin Syrup 2 g PO single 24 h

H

Hydrochlorothiazide

Trade and Other Names:
Vetazide, Hydro Aquil, Hydrodiuril Urozide, Edemol
Type of Drug:
Diuretic
Route of Administration:
IV, Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Hydrochlorothiazide
#Horses Product Dose/Route Administration EG
4 Vetazide 100 mg IV single 60 h
4 Hydro Aquil 225 mg PO single 60 h

Hydrocortisone

Trade and Other Names:
Solu-Cortef, Cortavance
Type of Drug:
Corticosteroid
Route of Administration:
IV, TOP
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Hydrocortisone
#Horses Product Dose/Route Administration EG
4 Solu-Cortef 250 mg IV single 48 h
4 Cortavance 152 µg PO single 24 h

Hydroxyzine

Trade and Other Names:
Hydroxyzine
Type of Drug:
Antihistamine
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Hydroxyzine
#Horses Product Dose/Route Administration EG
4 Hydroxyzine 500 mg PO twice daily, 5 days 96 h

I

Ibuprofen

Trade and Other Names:
Motrin
Type of Drug:
Analgesic, Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Ibuprofen
#Horses Product Dose/Route Administration EG
4 Motrin 12 g PO single 48 h

Indapamide

Trade and Other Names:
Lozide
Type of Drug:
Diuretic
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Indapamide
#Horses Product Dose/Route Administration EG
4 Lozide 40 mg PO single 48 h

Indomethacin

Trade and Other Names:
Indocid, Infrocin, Novomethacin
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Indomethacin
#Horses Product Dose/Route Administration EG
4 Indocid 1 g PO single 48 h

Ipratropium Bromide

Trade and Other Names:
Atrovent
Type of Drug:
Bronchodilator
Route of Administration:
AER
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Ipratropium Bromide
#Horses Product Dose/Route Administration EG
4 Atrovent 0.18 mg AER once daily, 3 days 24 h

Isoflupredone

Trade and Other Names:
Predef 2X
Type of Drug:
Corticosteroid
Route of Administration:
IA
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Isoflupredone
#Horses Product Dose/Route Administration EG
4 Predef 2X 10 mg IA single 6 days

K

Ketamine

Trade and Other Names:
Ketaset, Ketalar, Vetalar
Type of Drug:
General Anesthetic
Route of Administration:
IV
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Ketamine
#Horses Product Dose/Route Administration EG
4 Ketaset 700 mg IV single 96 h

Ketoprofen

Trade and Other Names:
Ketofen, Anafen
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
IV
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Ketoprofen
#Horses Product Dose/Route Administration EG
4 Anafen 1.2 g IV single 48 h

Ketotifen

Trade and Other Names:
Zaditen
Type of Drug:
Mast cell stabilizer
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Ketotifen
#Horses Product Dose/Route Administration EG
4 Zaditen 20 mg PO single 36 h

L

Lidocaine

Trade and Other Names:
Lignocaine, Xylocaine, Duracaine, Lido, Octocaine, Lignospan
Type of Drug:
Local Anesthetic
Route of Administration:
INFIL, TOP
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Lidocaine
#Horses Product Dose/Route Administration EG
4 Lidocaine Neat 150 mg INFIL single 24 h
4 Lidocaine Neat 500 mg TOP [a] single 36 h
[a] Topical product also contains 18 g DMSO

M

Meclofenamic Acid

Trade and Other Names:
Arquel
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Meclofenamic Acid
#Horses Product Dose/Route Administration EG
4 Arquel 1 g PO single 48 h
4 Arquel 1 g PO once daily, 3 days 48 h

Mefenamic Acid

Trade and Other Names:
Ponstan
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Mefenamic Acid
#Horses Product Dose/Route Administration EG
8 Ponstan 2 g PO single 48 h

Meloxicam

Trade and Other Names:
Metacam, Meloxicam Oral Suspension
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
IV, Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Meloxicam
#Horses Product Dose/Route Administration EG
4 Metacam 270 mg IV single 72 h
4 Meloxicam Oral Suspension 250 mg PO single 72 h

Mepivacaine

Trade and Other Names:
Carbocaine
Type of Drug:
Local Anesthetic
Route of Administration:
IA, SC
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Mepivacaine
#Horses Product Dose/Route Administration EG
4 Carbocaine 300 mg SC single 48 h
3 Carbocaine 250 mg IA single 72 h

Methocarbamol

Trade and Other Names:
Robaxin
Type of Drug:
Skeletal Muscle Relaxant
Route of Administration:
IV, Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Methocarbamol
#Horses Product Dose/Route Administration EG
4 Robaxin 5 g IV single 24 h
4 Robaxin 5 g PO single 24 h
4 Robaxin 3 g PO twice daily for 4 days and once on day 5 48 h

Methylprednisolone

Trade and Other Names:
Veterinary Depo Medrol
Type of Drug:
Corticosteroid
Route of Administration:
IA
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Methylprednisolone
#Horses Product Dose/Route Administration EG
4 Veterinary Depo Medrol 100 mg IA single 6 days
4 Veterinary Depo Medrol 200 mg IA single 14 days

N

Nabumetone

Trade and Other Names:
Relafen
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Nabumetone
#Horses Product Dose/Route Administration EG
4 Relafen 5 g PO single 96 h

Naproxen

Trade and Other Names:
Naprosyn, Equiproxen
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Naproxen
#Horses Product Dose/Route Administration EG
4 Naprosyn 4.5 g PO single 96 h
4 Equiproxen 2 g PO twice daily, 5 days 120 h

Nedocromil

Trade and Other Names:
Tilade, Alocril
Type of Drug:
Mast cell stabilizer
Route of Administration:
AER
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Nedocromil
#Horses Product Dose/Route Administration EG
4 Tilade 16 mg AER single 24 h

O

Oxaprozin

Trade and Other Names:
Daypro
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Oxaprozin
#Horses Product Dose/Route Administration EG
4 Daypro 4.8 g PO single 120+ h

Note: At this dosage, most horses would test positive for longer than 120 hours after the last treatment.

P

Pentazocine

Trade and Other Names:
Talwin
Type of Drug:
Opioid
Route of Administration:
IM
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Pentazocine
#Horses Product Dose/Route Administration EG
4 Talwin 300 mg IM single 72 h

Pentoxifylline

Trade and Other Names:
Trental, Navicon
Type of Drug:
Xanthine derivative
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Pentoxifylline
#Horses Product Dose/Route Administration EG
4 Trental 4 g PO single 48 h
4 Navicon 2 g PO twice daily, 4 days 48 h
4 Navicon 2 g PO three times daily, 5 days 48 h

Phenothiazine

Trade and Other Names:
Phenothiazine
Type of Drug:
Antipsychotic
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Phenothiazine
#Horses Product Dose/Route Administration EG
4 Phenothiazine Drench Grade Powder 4.75 g PO single 96 h

Phenylbutazone

Trade and Other Names:
Bute, Butazolidin, Dinz, Butazone, Equipalazone, Azrabute, Centrebute
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
IV, Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Phenylbutazone
#Horses Product Dose/Route Administration EG
2 Phenylbutazone Injectable 2 g IV once daily, 5 days 48 h
2 Phenylbutazone Injectable 2 g IV single 48 h
2 Bute 3 g PO single 96 h
2 Bute 3 g PO once daily, 3 days 96 h
2 Phenylbutazone Injectable 3 g IV once daily, 5 days 96 h
2 Phenylbutazone Injectable 3 g IV single 96 h

Phenytoin

Trade and Other Names:
Dilantin, Phenytoin Suspension
Type of Drug:
Anticonvulsant
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Phenytoin
#Horses Product Dose/Route Administration EG
4 Phenytoin Suspension 3 g PO twice daily, 3 days 96 h

Piroxicam

Trade and Other Names:
Feldene
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Piroxicam
#Horses Product Dose/Route Administration EG
4 Feldene 100 mg PO single 72 h

Prednisolone

Trade and Other Names:
Solu Delta Cortef (prednisolone sodium succinate), Prednisolone Acetate
Type of Drug:
Corticosteroid
Route of Administration:
Oral (PO), IV
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Prednisolone
#Horses Product Dose/Route Administration EG
8 Prednisolone Acetate 400 mg PO twice daily, 5 days 48 h
4 Solu Delta Cortef 500 mg IV single 48 h
4 Solu Delta Cortef 100 mg IV single 48 h

Prednisone

Trade and Other Names:
Deltasone
Type of Drug:
Corticosteroid
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Prednisone
#Horses Product Dose/Route Administration EG
4 Deltasone 1 g PO single 48 h

Procaine Hydrochloride

Trade and Other Names:
Novocain
Type of Drug:
Local Anesthetic
Route of Administration:
INFIL
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Procaine Hydrochloride
#Horses Product Dose/Route Administration EG
4 Novocain 80 mg INFIL single 48 h
4 Novocain 120 mg INFIL single 48 h
4 Novocain 160 mg INFIL single 48 h
4 Novocain 200 mg INFIL single 48 h
4 Novocain 1600 mg INFIL single 48 h

Penicillin G Procaine

Trade and Other Names:
Derapen A, Azimycin, Cillimycin, Penamycin, Pen-Strep Suspension, Pen Di Strep, Procillin, Ethacillin, Diathol
Type of Drug:
Antibiotic (contains local anesthetic component: Procaine)
Route of Administration:
IM
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Penicillin G Procaine
#Horses Product Dose/Route Administration EG
4 Derapen A 2 million IU [a] IM single 425 h
4 Azimycin 4 million IU IM single 425 h
4 Cillimycin 4 million IU IM single 425 h
4 Penamycin 4 million IU IM single 425 h
4 Pen-Strep Suspension 4 million IU IM single 425 h
4 Pen Di Strep 4 million IU IM single 425 h
4 Pen Di Strep 4 million IU IM once daily, 5 days 425 h
4 Ethacillin 6 million IU IM single 425 h
4 Diathol [b] 2 million IU IM single 425 h
[a] IU= International Units (1 million IU Penicillin G Procaine contains 424 mg Procaine)
[b] Also contains 200 mg procaine hydrochloride

Pyrilamine

Trade and Other Names:
Histosol, Anti-Histamine (also contains Ephedrine)
Type of Drug:
Antihistamine
Route of Administration:
IM, Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Pyrilamine
#Horses Product Dose/Route Administration EG
4 Histosol 500 mg IM single 36 h
4 Anti-Histamine 750 mg PO twice daily, 6 days 36 h

R

Ranitidine

Trade and Other Names:
Zantac
Type of Drug:
Histamine H2 Receptor Antagonist
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Ranitidine
#Horses Product Dose/Route Administration EG
4 Zantac 3 g PO twice daily, 4 days 48 h

Reserpine

Trade and Other Names:
Reserpine
Type of Drug:
Tranquilizer
Route of Administration:
IM
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Reserpine
#Horses Product Dose/Route Administration EG
4 Reserpine 2.5 mg IM single 7 days

Romifidine

Trade and Other Names:
Sedivet
Type of Drug:
Analgesic; Sedative
Route of Administration:
IV
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Romifidine
#Horses Product Dose/Route Administration EG
4 Sedivet 20 mg IV single 36 h
4 Sedivet 50 mg IV single 36 h

S

Salbutamol

Trade and Other Names:
Ventolin
Type of Drug:
Bronchodilator
Route of Administration:
AER
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Salbutamol
#Horses Product Dose/Route Administration EG
4 Ventolin 0.8 mg AER single 24 h

Salicylic Acid
Acetylsalicylic Acid (ASA, Aspirin)
Methyl Salicylate

Trade and Other Names:
Acetophen, Entrophen, Aspir (ASA); others (Methyl salicylate)
Type of Drug:
Antipyretic/analgesic/Anti-inflammatory (NSAID): ASA; Counterirritant : Methyl salicylate ; Keratolytic : Salcylic Acid
Route of Administration:
Oral (PO)  
Dosage Regimen and Elimination Guideline (EG):
Dosage Regimen and Elimination Guideline for Salicylic Acid
#Horses Product Dose/Route Administration Salicylic Acid Levels
Blood>6.5µg/mL
Urine>750µg/mL
12 Acetophen 11.7g PO Acetylsalicylic acid 24 h[a]
[a] Acetylsalicylic acid was detected in horse urine up to 14 hours in this experiment. No levels greater than 750 µg/mL in urine or 6.5 µg/mL in blood were observed as a result of feed administration.

Note: All of the above results are based on experiments and analysis of horse urine using current methodology. It is stressed that these results are presented as guidelines only. They should not be construed as absolute for every horse administered a drug metabolized to salicylic acid.

Salmeterol

Trade and Other Names:
Serevent
Type of Drug:
Bronchodilator
Route of Administration:
AER
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Salmeterol
#Horses Product Dose/Route Administration EG
4 Serevent 0.25 mg AER single 24 h

Sulindac

Trade and Other Names:
Clinoril
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Sulindac
#Horses Product Dose/Route Administration EG
4 Clinoril 1.0 g PO single 96 h

T

Tenoxicam

Trade and Other Names:
Mobiflex
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Tenoxicam
#Horses Product Dose/Route Administration EG
4 Mobiflex 200 mg PO single 48 h

Terbutaline

Trade and Other Names:
Bricanyl, Brethine
Type of Drug:
Bronchodilator
Route of Administration:
Oral (PO), SC
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Terbutaline
#Horses Product Dose/Route Administration EG
4 Brethine 1 mg SC single 72 h
4 Bricanyl 40 mg PO single 72 h

Theophylline

Trade and Other Names:
Aminophylline: Somophyllin, Aminophyl, Corophyllin, Phyllocontin, Theophylline: Acet-Am, Quibron, Asthmophylline, Theolair, AA-THEO LA
Type of Drug:
Bronchodilator
Route of Administration:
IV, Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Theophylline
#Horses Product Dose/Route Administration EG
4 Aminophylline 1.5 g IV single 96 h
4 AA-THEO LA 4 g PO Single 72 h

Tiaprofenic Acid

Trade and Other Names:
Surgam
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Tiaprofenic Acid
#Horses Product Dose/Route Administration EG
4 Surgam 2.4 g PO single 120 h

Triamcinolone Acetonide

Trade and Other Names:
Kenalog-10, Vitaderm-K.C.
Type of Drug:
Corticosteroid
Route of Administration:
IA, TOP
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Triamcinolone Acetonide
#Horses Product Dose/Route Administration EG
4 Kenalog-10 20 mg IA single 6 days
4 Vitaderm-K.C. 10 mg TOP Single 24 h

Trichlormethiazide

Trade and Other Names:
Naquasone
Type of Drug:
Diuretic
Route of Administration:
Oral (PO), IV, IM
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Trichlormethiazide
#Horses Product Dose/Route Administration EG
4 Naquasone 100 mg PO single 48 h
4 Naquasone 200 mg PO single 48 h
4 Naquasone 100 mg IV single 48 h
4 Naquasone 100 mg IM single 48 h

Tripelennamine

Trade and Other Names:
Vetastim
Type of Drug:
Antihistamine
Route of Administration:
IM
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Tripelennamine
#Horses Product Dose/Route Administration EG
4 Vetastim 400 mg IM single 36 h

V

Vedaprofen

Trade and Other Names:
Quadrisol
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO), IV
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Vedaprofen
#Horses Product Dose/Route Administration EG
4 Quadrisol 1 g PO once daily on days 1 & 5; 0.5 g twice daily on days 2-4 48 h
4 Quadrisol 1 g IV single 48 h

X

Xylazine

Trade and Other Names:
Rompun
Type of Drug:
Analgesic; Sedative
Route of Administration:
IV
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Xylazine
#Horses Product Dose/Route Administration EG
4 Rompun 500 mg IV single 48 h

Z

Zomepirac

Trade and Other Names:
Zomax
Type of Drug:
Analgesic/Anti-inflammatory (NSAID)
Route of Administration:
Oral (PO)
Dosage Regimen and Elimination Guideline (EG):
 
Dosage Regimen and Elimination Guideline for Zomepirac
#Horses Product Dose/Route Administration EG
2 Zomax 0.5 g PO single 96 h
2 Zomax 0.5 g PO once daily, 3 days 96 h
2 Zomax 1 g PO single 96 h
2 Zomax 1 g PO once daily, 3 days 96 h

Warning

It is stressed that these results are presented as guidelines only and should not be construed as absolute for every horse to which this drug is administered.

The guidelines in this booklet may not apply to a compounded product and may not be consistent with foreign regulations and laboratory methods.

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